Carica papaya (CP) is a member of the Caricaceae and is a dicotyledonous, polygamous, and diploid species. It originated from Southern Mexico, Central America, and the northern part of South America. It is now cultivated in many tropical countries such as Bangladesh, India, Indonesia, Sri Lanka, the Philippines, West Indies and Malaysia.

The papaya fruit is globally consumed either in its fresh form or the form of juices, jams, and crystallized dry fruit. The ripe fruit is said to be a rich source of vitamin A, C, and calcium. There are many commercial products derived from the different parts of the C. papaya plant, the most prominent being papain and chymopapain, which is produced from the latex of the young fruit, stem, and the leaves.

The leaves of papaya have been shown to contain many active components that can increase the total antioxidant activity in blood and reduce lipid peroxidation level, such as papain, chymopapain, cystatin, tocopherol, ascorbic acid, flavonoids, cyanogenic-glucosides and glucosinolates.

The alkaloids, flavonoids, saponins, tannin, and glycosides are related with anti- inflammatory activity. CP leaves extract also found to have anti-bacterial effect, anti tumor, and immunomodulator activities. The leaf of CP is categorized as non toxic because its LD50 > 15 g per kg body weight. The leaves also contain cardiac glycosides, anthraquinones, carpaine, pseudocarpaine, phenolic compounds.

In addition to the nutritional value of its fruit, the leaves of CP possess medicinal properties and are widely used in traditional medicines. Previous studies on papaya have shown that seed extract of CP possess pharmacological activities, including anthelminthic, antifertility, contraceptive etc. A hot-water extract of the leaves is taken orally as an antipyretic, and treatment of anemia, appetite stimulation. In many countries the leaves extract of CP had been effectively used for treatment of dengue fever (DF) associated with thrombocytopenia.

Carica Papaya Leaf extract is extracted from the dried leaves of the Carica Papaya plant commonly known as the Papaya plant. Special care is taken to ensure that the leaves are sourced from special pre audited and pre-approved plantations that follow good agricultural practices.

The leaves are specially handpicked, cleaned, sun dried and tested for their medicinal content. Only those leaves which pass all these tests are used for the extraction process.

The dried leaves are powdered and the active substance responsible for the beneficial activity of papaya leaf extract - Glycosides and Polyphenols are extracted by a special proprietary extraction process. The extract is further dried and standardized to give a final product which contains not less than 40% Glycosides and 3% polyphenols.

The finished product is subjected to stringent validated Quality Control tests to ensure that we get a standardized finished product conforming to global standards batch after batch.

Normally, herbal extracts are associated with heavy metal and microbial contamination. However, the Carica Papaya extract in Caripill is subjected to in house tests to ensure that the finished product is free from microbial and heavy metal contamination.

The production and Quality Control /Quality Assurance SOP’s followed are similar to those followed for allopathic formulations.

Carica Papaya Leaf Extract in Caripill

The Carica Papaya Leaf extract used in Caripill is manufactured in accordance with globally accepted GMP norms. Given below is a table that compares the Carica Papaya Leaf Extract in Caripill with those products produced by other manufacturers.